Frewitt
Milling & Sizing Equipment
Pharmaceutical Milling from Lab to Production Scale
Particle size distribution directly affects dissolution rate, blend uniformity, content uniformity, and ultimately bioavailability, making milling one of the most consequential unit operations in solid dose manufacturing. Frewitt Ltd., founded in 1946 in Granges-Paccot, Switzerland, is a specialist in dry and wet milling processes for the pharmaceutical, fine chemical, and food industries. The company’s origins trace to a patented vibrating and oscillating sieve technology developed in the 1950s, still the foundation of the current oscillating mill line.
Frewitt’s mill portfolio is organized across three platforms of increasing capability (EasyMill, FlexMill, and PowerMill), each offering interchangeable milling heads (conical, oscillating, hammer, pin, rotating sieve) on a shared drive unit. Beyond milling, Frewitt provides containment, dosing, and handling accessories for complete powder processing solutions. ISO 9001 and ISO 14001 certified; ATEX certified equipment available.
MHS Pharma represents Frewitt across the Northeast United States, supporting pharmaceutical manufacturers and CDMOs with equipment selection for size reduction applications from development through commercial manufacturing.
Why Frewitt
Modular Multi-Head Platform
One drive unit accommodates multiple milling heads: conical sieve, oscillating sieve, hammer, pin mill, and rotating sieve. Switch milling processes without changing the base unit. Three platforms (EasyMill, FlexMill, PowerMill) scale from lab through production with consistent milling principles.
Micronization to Nano Scale
When bioavailability depends on surface area, particle size becomes a critical quality attribute. Pin mills (PMC series) achieve D90 down to 8 µm for dry micronization. The NanoWitt wet bead mill reaches D50 to 50 nm. Cryogenic modules (CryoFeeder CF-25) enable milling of heat-sensitive, elastic, or waxy materials at temperatures down to -80 °C.
Containment to OEB 5
Full containment options across the product line: ProFi-OEB high-containment milling system, ProFi-Flex flexible isolators, ProFi-Liner continuous liner discharge, and a mobile rigid isolator with universal fit. Validated OEB 5 configurations for potent compound processing.
Design Space That Transfers
The FlexMill-Lab offers six milling processes in one modular unit. Because production-scale FlexMill and PowerMill systems use the same milling principles and head geometries, the process understanding and operating ranges established at lab scale carry forward. The design space you define in development is the design space you validate in production.
Applications
Frewitt equipment serves pharmaceutical size reduction across the full process chain:
- Size reduction of granulated and dried pharmaceutical powders
- Dry and wet milling for solid dose formulation development
- Micronization and fine grinding of APIs (D90 to 8 µm)
- Cryogenic milling of heat-sensitive, elastic, or waxy compounds
- High-potency compound milling with full containment (OEB 4–5)
- Inline milling between process steps (post-drying, pre-blending)
Equipment Range
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Precision calibration mills for controlled particle size reduction. Available as FlexMill CW (modular, multi-process) and EasyMill CM (standard) in lab and production scales. Conical sieve geometry provides gentle, consistent size reduction. Lab to 5,000 kg/h · FlexMill & EasyMill platforms · Interchangeable heads |
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Gentle size reduction using Frewitt’s patented vibrating and oscillating sieve technology, the company’s original innovation from the 1950s. Ideal for friable granules and shear-sensitive materials where preserving particle structure is critical. OW-1 (lab, to 100 kg/h) · OW-3 / OW-6 (production, to 2,000 kg/h) · Patented technology |
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High-energy impact mills for coarse to fine size reduction. FlexMill HW and EasyMill HM series at lab and production scale. The PowerMill MFH-15 Multi-Function Hammer delivers the highest throughput with particle sizes down to 30 µm. Lab to 5,000 kg/h · Down to 30 µm (MFH-15) · Cryo option available |
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High-speed pin mills for fine grinding and micronization. The PMC-160 (lab/pilot) achieves D90 down to 8 µm; the PMC-260 scales to production throughput. Both available with cryogenic cooling for temperature-sensitive APIs. The PowerMill PMV-320 offers a patent-protected safe pin mill design. D90 to 8 µm · PMC-160 (lab) & PMC-260 (production) · Cryo option · Up to 1,000 kg/h |
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Inline crushers for breaking up agglomerates, compressed blocks, and caked powders. The CC-2 dual-mode crusher fits the FlexMill platform; CC-3 and CC-6 handle large-input crushing. The PowerMill DW-250 reduces 60 cm lumps to 250 µm in a single step. Up to 20,000 kg/h · 60 cm input to 250 µm output (DW-250) · Inline between dryers & downstream |
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Cryogenic milling systems using the CryoFeeder CF-25 LN₂ cooling module to chill material before milling, enabling brittle fracture of heat-sensitive, elastic, or waxy compounds that are otherwise unmillable. Available with pin mill and hammer mill heads. Down to -80 °C · LN₂ CryoFeeder · Pin mill & hammer mill cryo variants |
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Inline sifting for classification, safety screening, and deagglomeration. Available as FlexMill SW and EasyMill RS heads, integrating directly into the modular mill platform for closed-loop size reduction and screening workflows. FlexMill SW & EasyMill RS · Lab & production · Inline integration |
MHS Pharma — Northeast US Representative
MHS Pharma provides direct technical representation for Frewitt across the Northeast United States. We work with pharmaceutical manufacturers and CDMOs on milling equipment projects, from process development and scale-up through commercial installation.
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