3V Tech
Drug Substance (API) Process Equipment
Reaction, Filtration & Drying Equipment for API Manufacturing
API manufacturing is fundamentally about closed processing: moving from reaction through isolation through drying with minimal product exposure and full traceability at every step. 3V Tech S.p.A. is an Italian provider of advanced process equipment and turnkey plants built around that principle, serving the pharmaceutical, chemical, and fine chemical industries. Part of the 3V Group, an Italian multinational founded in 1958, 3V Tech was formed by combining three specialist companies (process filtration/drying, glass-lined enamel, and thermal separation), bringing deep expertise in reaction, filtration, drying, and evaporation under one roof.
3V Tech manufactures in glass-lined steel, borosilicate glass, 316L stainless, Hastelloy C-22, and specialty alloys, with a catalog of 44 distinct products covering the full drug substance workflow from synthesis through isolation and drying. Manufacturing facilities are located in Italy (Bergamo, Dalmine, Noventa Di Piave, Assisi) and the USA (Andrews, SC).
MHS Pharma represents 3V Tech across the Northeast United States, supporting pharmaceutical manufacturers and CDMOs with equipment selection, process engineering, and project coordination for API facility builds and upgrades.
Why 3V Tech
Coordinated Process Train
Process consulting through fabrication to after-sales service under one roof. 3V Tech designs reactors, filters, and dryers as a coordinated process train, each vessel engineered to receive from the upstream step and discharge to the next with minimal open handling. Fewer transfer steps means less product exposure, less yield loss, and a simpler validation scope across the full API workflow.
Materials Matched to Chemistry
Material of construction is a process design decision driven by the chemistry: solvent compatibility, temperature range, corrosion profile, and cleaning requirements all dictate whether a vessel should be glass-lined steel, borosilicate glass, Hastelloy, or specialty alloy. 3V Tech manufactures across all of these, with the proprietary G2208 glass-lining family (Standard, SIGMA, PHI, and TRANSLUCENT variants) engineered for specific corrosion and process conditions.
Lab Through Production Scale
From benchtop glass lab reactors through pilot-scale EASYCHEM systems to full-scale glass-lined reactors up to 6,300 L and horizontal dryers up to 22,000 L. Equipment can be supplied as standalone units or as part of modular turnkey plants.
Purpose-Built for Pharma
cGMP-compliant design with clean-in-place capability, full documentation packages, and regulatory-ready construction. Equipment designed for pharmaceutical environments from the ground up. CIP-capable vessels reduce manual cleaning interventions, while containment options support HPAPI processing where the compound’s occupational exposure limit demands closed-system handling from charge through discharge.
Applications
3V Tech equipment serves the full drug substance manufacturing workflow:
- Chemical synthesis and reaction (batch and semi-batch)
- API isolation: filtration, cake washing, and drying in a single vessel
- Vacuum drying of pharmaceutical intermediates and APIs
- Solvent recovery, distillation, and concentration
- High-potency API (HPAPI) processing with containment
- Process scale-up from kilo lab through commercial manufacturing
Equipment Range
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Glass-Lined Reactors Jacketed glass-lined steel reactors for pharmaceutical synthesis in corrosive chemistries. Available in DIN and ASME configurations across six reactor types, with options for pressure, vacuum, and cryogenic operation. Proprietary G2208 glass-lining technology with Standard, SIGMA, PHI, and TRANSLUCENT variants. 63–6,300 L · -1 to +6 bar · -25 to +200 °C · DIN & ASME standards · 4 glass-lining types |
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Filter Dryers (Filtrodry) Combined pressure filtration and vacuum drying in a single vessel, processing concentrated slurry and discharges dry powder without operator exposure or external product transfer. Available in single discharge (SD), top discharge (TD), extended discharge (XD), tilting (RFD), and glass-lined (GL) configurations. Filtration, washing, smoothing & drying in one vessel · Stainless & glass-lined · CIP capable |
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Vertical Dryers (Mixodry) Agitated vacuum dryers with a double-motion agitation group (auger + orbital arm) providing gentle mixing, particularly suitable for low-density substances. Efficient heat transfer through jacketed walls and full vacuum capability for temperature-sensitive compounds. 45–10,000 L · Vacuum to -1 bar · Double-motion agitation · Pharma & fine chemical |
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Nutsche Filters Agitated pressure filters for solid-liquid separation with integrated impurity removal. Performs filtration, cake smoothing, displacement washing, re-slurry washing, and CIP in one vessel without operator exposure. Available in stainless steel (FPP) and glass-lined (FPP/GL) configurations. Filter area up to 16 m² · Stainless & glass-lined · Multi-step washing · HPAPI capable |
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Horizontal Dryers Horizontal paddle vacuum dryers with heated agitator providing continuous wall contact for efficient heat transfer. Steridry EP and ES for sterile pharmaceutical applications; Chemidry EC for chemical processing at the largest scale in the 3V Tech dryer range. Up to 22,000 L · Vacuum capable · Sterile (Steridry) & chemical (Chemidry) variants |
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Evaporators Vertical and horizontal thin film evaporators, short path evaporators, and falling film evaporators for solvent recovery, concentration, and distillation. High-speed rotor maintains a turbulent film against the heated wall. Short contact time makes them suitable for thermally sensitive products. 0.15–40 m² evaporating surface · 4 evaporator types · High viscosity & fouling capable |
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Glass Lab & Pilot Reactors Borosilicate glass reactor systems for R&D and pilot-scale work. EASYCHEM modular reactors on freestanding movable frames for synthesis, crystallization, and polymerization. Pharma reactors with FDA-approved PTFE sealing. Lab-scale configurators available for custom setups. Lab to 100 L · Trolley-mounted · GMP-compliant · EASYCHEM, Pharma & Lab reactor lines |
MHS Pharma — Northeast US Representative
MHS Pharma provides direct technical representation for 3V Tech across the Northeast United States. We work with pharmaceutical manufacturers, CDMOs, and engineering firms on API equipment projects, from process requirements through commissioning and qualification.
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