Glass Lab and Pilot Reactors
Development-Scale Glass Reactors — 3V Tech
Overview
3V Tech builds jacketed borosilicate glass reaction systems that carry a project from the bench through pilot scale on a continuous design family. The Lab Scale Reactor handles 300 mL to 7 L, the EasyChem pilot reactor covers 5 L to 100 L, and the GMP Glass Pharma Reactor is offered in 10 L, 20 L, 30 L, and 50 L nominal capacities. Each is built with the same materials used in industrial chemical processes, so chemistry developed at lab scale transfers cleanly to pilot batches.
Every system is a complete unit on a free-standing movable frame: reaction vessel, lid, stirring system, condenser, feeding and collection vessels, and a bottom discharge valve. Only PTFE and borosilicate glass contact the product, and the transparent vessel allows visual monitoring of reaction progress throughout the run. The lab and pilot frames are compact enough to place on a bench or under a walk-in hood.
The Glass Pharma Reactor is designed for pharmaceutical GMP use and features 3V Tech’s proprietary Ultra GMP bottom discharge valve, with a glass body welded directly to the reactor for complete draining and no stagnant product. An integrated Pt100 probe can be placed inside the drain valve to read product temperature at very low liquid levels while freeing a lid nozzle.
Glass Pharma Reactor: GMP certified bottom valve, CE Machinery Directive, ATEX available on request for flammable solvent service.
Range and Working Conditions
| Lab Scale Reactor | 300 mL to 7 L, design temperature -50 °C to +200 °C, design pressure -1 barg to +0.5 barg |
| EasyChem pilot reactor | 5 L to 100 L, design temperature -50 °C to +200 °C, design pressure -1 barg to +0.5 barg |
| Glass Pharma Reactor | 10 L, 20 L, 30 L, 50 L, design temperature -50 °C to +180 °C, design pressure 1 mbar to 0.49 bar |
| Max vacuum | 10 mbar(a) lab and pilot; 5 mbar Glass Pharma Reactor |
| Heating media | Steam, hot oil, or hot water |
Construction and Materials
| Reaction vessel | 3.3 borosilicate glass, jacketed |
| Lid | 3.3 borosilicate glass or PTFE, PTFE/glass coupling |
| Product contact surfaces | Glass, PTFE, FEP, PEEK |
| Stirring shaft | AISI 304 stainless steel, PTFE coated, with PTFE anchor blade |
| Mechanical seal | PTFE/PEEK/glass (lab and small pilot); PTFE/glass (larger pilot); magnetic drive option |
| Bottom valve | Standard removable valve or GMP/Ultra GMP valve with thermal compensation |
| Support frame | AISI 304 stainless steel, free-standing, on wheels |
Key Features
Continuous Lab to Pilot Family
One material set spans 300 mL through 100 L, so reactions developed at the bench scale up to pilot batches without changing the wetted chemistry.
Ultra GMP Bottom Valve
On the Glass Pharma Reactor the glass valve body is welded directly to the vessel for complete draining with no product hold-up, and constant closure pressure during temperature changes.
PTFE and Glass Product Contact
Only PTFE and borosilicate glass touch the product, removing metal contamination and supporting FDA compliant GMP service.
Pt100 Probe in the Valve
An optional Pt100 sensor sits inside the drain valve to read product temperature at very low liquid levels, frees a lid nozzle, and responds faster than a lid-mounted sensor.
Complete System on a Movable Frame
Reactor, feeding vessel, condenser, collection vessel, and stirring system arrive together on a free-standing wheeled frame that fits a bench or a walk-in hood.
Visual Process Monitoring
The transparent borosilicate vessel lets operators watch crystallization, mixing, and reaction progress directly throughout the batch.
Applications
- Pharmaceutical API synthesis and crystallization
- Small-scale reaction screening and process development before scale-up
- Solvent distillation and recovery
- Temperature-controlled reactions from -50 °C to +200 °C
- GMP-compliant batch reactions requiring complete product drainage
- Emulsion, formulation, and enzyme digestion studies
MHS Pharma — Northeast US Representative
MHS Pharma provides direct technical representation for 3V Tech across the Northeast United States. Contact us to discuss glass lab and pilot reactor systems for your development and kilo-lab process needs.
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