ChargePoint Actis Aseptic Transfer System
Sterility Assurance Built Into the Connection — ChargePoint Technology
Overview
ChargePoint Actis is a new category of aseptic transfer system, launched in September 2026. It brings together three proven approaches in one unit: the barrier integrity of an isolator, the direct transfer efficiency of a split butterfly valve, and the established sealing of a rapid transfer port. The critical transfer surfaces are enclosed within a fully steam-sterilized chamber, and the transfer path bypasses the ring of concern entirely: the ring-shaped interface at the outer sealing surfaces where two environment-exposed faces normally meet. In Actis, the surfaces that come together at the connection have only ever been exposed to a penetrative sterilization process, never to the external environment.
The result is validated sterility assurance and double containment, both primary and secondary, in a single direct transfer system. Actis addresses the aseptic transfer requirements of EU GMP Annex 1 in one system: closed transfer, reduced manual handling, protection of first air, and penetrative sterilization of product contact surfaces. It goes a step further by also steam-sterilizing all secondary sterile boundary interfaces.
Rated OEB6+ containment and SAL 10-6 sterility assurance. Patent pending. First size 100 mm (4″), with further sizes to follow.
Technical Data
| Containment performance | OEB6+ |
| Sterility performance | SAL 10-6 |
| Cleaning & sterilization | Integrated CIP / SIP (steam sterilization) |
| Sterilization method | Active unit: steam-in-place. Passive unit: autoclave |
| Chamber | Sealed, pressure-rated to 2.5 barG, fully drainable after CIP/SIP |
| Connection | Tri-clamp |
| Size | 100 mm (4″), further sizes to follow |
| Product contact materials | 316L stainless steel, platinum-cured silicone (FDA / USP Class VI compliant) |
| Drives | 4 stepper motors with smooth motion control to minimize particulate generation |
| Control system | Remote I/O module over Industrial Ethernet, running ChargePoint-supplied code on the customer’s PLC and HMI |
| Mounting | Externally mounted, modular, multiple mounting configurations |
| IP status | Patent pending |
How a Transfer Runs
Powder sealing and containment sealing are separated functions: the split disc halves seal the powder path, while the doors and chamber seal the containment boundary. A full cycle runs in four stages, fully automatic with no manual interventions:
- Dock. A pre-sterilized container carrying the passive disc and door docks onto the active unit and locks into place.
- Transfer. The internal doors retract, a chute extends to form a sterile-to-sterile connection, and the disc opens for direct transfer. No intermediate container, no double handling.
- Clean and sterilize, primary. Integrated spray heads clean and steam-sterilize all primary contact surfaces and the transfer chute via CIP/SIP.
- Clean and sterilize, secondary. A second CIP/SIP position exposes all secondary sterile boundary interfaces to the sterilization cycle, followed by a drying sequence.
The sealed 2.5 barG chamber is what allows cleaning and sterilization to run in place: no offline sterilization, no aseptic assembly, and multiple transfers can follow one qualified sterilization cycle.
Key Features
Sterile-to-Sterile Connection
The transfer path bypasses the ring of concern entirely. Only surfaces that have been through a penetrative sterilization process ever meet at the connection.
Annex 1 Alignment in One System
Closed transfer, reduced manual handling, protection of first air, and penetrative sterilization of product contact surfaces, addressed together rather than by separate infrastructure layers.
OEB6+ Double Containment
Primary and secondary containment in a single system improves operator protection for potent compounds and reduces reliance on manual cleaning and PPE.
Integrated CIP / SIP
Spray heads clean and steam-sterilize the system in place inside the sealed chamber, removing aseptic assembly, offline cleaning, and manual wipe-downs.
Multiple Transfers per Cycle
Several consecutive transfers can follow a single qualified sterilization cycle, with direct transfer and no double handling in between.
Lower-Grade Room Operation
Supports aseptic transfer with the surrounding cleanroom at Grade D, C or B, reducing the capital, floor space, and operating cost of the space around the transfer point.
Actis LITE
Actis LITE is a simplified variant for weigh and dispense steps, integrated into the isolator for filling of the intermediate container in either aseptic or high-containment execution. It keeps a low-profile, GMP design that washes down with the isolator, and unlike the full Actis it is compatible with both steam sterilization and bio-decontamination.
Applications
Actis suits any stage of drug substance and drug product production, from weigh and dispense through final filling and formulation:
- Powder filling
- Compounding and suspension preparation
- Dispensing
- Freeze drying and microsphere formulation
- Milling and sieving
- Cleaning and sterilization
MHS Pharma — Northeast US Representative
MHS Pharma provides direct technical representation for ChargePoint Technology across the Northeast United States. Actis will be on display at Interphex New York in April 2027. Contact us to discuss aseptic transfer for your process.
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